|
T8500 |
VLX600
|
|
OXPHOS
,
Mitochondrial Metabolism
,
Autophagy
|
|
VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells. |
|
T7093 |
Rafoxanide
|
|
CDK
,
Parasite
|
|
Rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer. Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookworm and other infestations. |
|
T9211 |
Mito-LND
|
Mito-Loidamine |
OXPHOS
,
Reactive Oxygen Species
,
Mitochondrial Metabolism
,
Autophagy
|
|
Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation. |
|
T5337 |
IACS-010759
|
IACS-10759,IACS 10759,IACS10759 |
Apoptosis
,
Others
,
Mitochondrial Metabolism
|
|
IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain. |
|
T8842 |
IMT1B
|
3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974 |
Others
,
DNA/RNA Synthesis
|
|
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it... |
|
T15373 |
Gboxin
|
|
ATPase
,
Mitochondrial Metabolism
|
|
Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity. |
|
T6834 |
FCCP
|
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone |
ATPase
,
Mitochondrial Metabolism
|
|
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer. |
|
T7081 |
CCCP
|
Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone |
Apoptosis
,
IκB/IKK
,
COX
,
Mitochondrial Metabolism
,
STING
,
IFNAR
,
Antibacterial
|
|
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules ... |
|
T9558 |
KL-11743
|
|
transporter
|
|
KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria. |
|
T8532 |
IM156
|
|
OXPHOS
|
|
IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in anima... |
|
T63136 |
DX3-213B
|
|
OXPHOS
|
|
DX3-213B is a potent, orally active inhibitor of oxidative phosphorylation (OXPHOS) complex I with an IC50 of 3.6 nM. DX3-213B blocks ATP production (IC50: 11 nM) and inhibits the growth of MIA PaCa-2 cells (GI50: 11 nM)... |
|
T36420 |
IM-156 acetate
|
HL271 acetate |
|
|
IM-156 acetate, an activator of NADH dehydrogenase (IC50=2.2 μM) and AMP-activated protein kinase alpha (AMPKα), is an orally available and bioavailable inhibitor of mitochondrial oxidative phosphorylation (OxPhos).IM-15... |
|
T8740 |
COH-SR4
|
COH-SR4 (Mitochondria uncoupler SR4) |
Others
,
AMPK
|
|
COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proli... |
|
T23579 |
13-Hydroxystevane
|
Kauran-13-ol |
|
|
13-Hydroxystevane shows an inhibitory action on oxidative phosphorylation. |
|
T30592 |
Bromethalin
|
EL-614,EL614,EL 614 |
|
|
Bromethalin works by uncoupling mitochondrial oxidative phosphorylation. |
|
T27041 |
Clidanac
|
Clidanaco,TAI 284,Britai,TAI-284,TAI284 |
|
|
Clidanac is a potent anti-inflammatory drug and is found to uncouple the oxidative phosphorylation. |
|
T28626 |
Rutamycin
|
Oligomycin D,A272,A 272,A-272 |
|
|
Rutamycin is a macrolide antibiotic of the oligomycin group obtained from Streptomyces rutgersensis. It inhibits various ATPases and uncouples oxidative phosphorylation from electron transport. |
|
T34472 |
S1QEL
|
S-1QEL,S1 QEL,S 1QEL,S1QEL1.1,S1-QEL |
|
|
S1QEL is a suppressor of mitochondrial respiratory complex I site IQ electron leak which suppresses superoxide and/or H2O2 production without altering oxidative phosphorylation. |
|
T32392 |
Sonlicromanol
|
KH-176,KH 176,KH176 |
|
|
KH-176 is an effective intracellular REDOX regulator that targets reactive oxygen species, which are important in the pathogenesis of mitochondrial oxidative phosphorylation disorders and may be used to treat mitochondri... |
|
T64004 |
DX3-234
|
|
|
|
DX3-234 is an inhibitor of oxidative phosphorylation (OXPHOS). In a Pan02 homozygous model of pancreatic cancer, DX3-234 exhibits significant tumour suppressive activity. |
|
T3689L |
Ruboxistaurin mesylate
|
LY-333531,LY333531,LY 333531,LY-333531 Mesylate |
|
|
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic ne... |
|
T62416 |
DX2-201
|
|
|
|
DX2-201 is a potent and selective inhibitor of oxidative phosphorylation (OXPHOS) complex I (IC50: 312 nM) and exhibits anticancer activity. |
|
T37612 |
IBTP (iodide)
|
|
|
|
IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner. As a result, mitochondrial proteins that have changed thiol redox state following oxidative s... |
|
T64108 |
DX3-235
|
|
|
|
DX3-235 is an inhibitor of oxidative phosphorylation (OXPHOS). In galactose-containing media, DX3-235 inhibits complex I function and ATP production by nanomolar amounts and is significantly cytotoxic. |
|
T62890 |
OXPHOS-IN-1
|
|
|
|
OXPHOS-IN-1 (compound 2) is an inhibitor of oxidative phosphorylation (OXPHOS) and inhibits the growth of MIA PaCa-2 cells (IC50: 2.34 μM) and BxPC-3 cells (IC50: 13.82 μM). |
|
T69990 |
Ruboxistaurin mesylate monohydrate
|
|
|
|
Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and... |
|
T74779 |
JNJ-28583113
|
|
|
|
JNJ-28583113, a TRPM2 antagonist with brain permeability, inhibits the phosphorylation of GSK3α and β subunits, thereby protecting cells from oxidative stress-induced cell death. Additionally, it suppresses cytokine rele... |
|
T79476 |
SCAL-255
|
|
Mitochondrial Metabolism
|
|
SCAL-255 is a mitochondrial complex I (CI) inhibitor, exhibiting potent inhibition with an IC50 of 1.14 μM. It impedes mitochondrial function by blocking oxygen consumption rate (OCR), inducing reactive oxygen species (R... |
|
T37632 |
TFM
|
|
|
|
TFM is a piscicide.1It is toxic to sea lamprey (P. marinus) with LC50values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for ... |
|
T79226 |
AMPK activator 11
|
|
Mitochondrial Metabolism
|
|
AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative... |
|
T79477 |
SCAL-266
|
|
Mitochondrial Metabolism
|
|
SCAL-266, a potent inhibitor of mitochondrial complex I (CI), exhibits an IC50 of 0.83 μM. This compound impairs mitochondrial function by blocking oxidative phosphorylation (OXPHOS), inhibiting oxygen consumption rate (... |
|
T73796 |
Acetyl coenzyme A lithium
|
|
|
|
Acetyl-coenzyme A (Acetyl-CoA) lithium, a membrane-impermeant central metabolic intermediate, is integral to the TCA cycle and oxidative phosphorylation. It regulates cellular mechanisms by serving as the sole donor of a... |
|
T79286 |
TRAP1-IN-2
|
|
HSP
|
|
TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients. It inhibits oxidative phosphorylation (OXPHOS) and shifts cellular metabolism towar... |
|
T73558 |
W1131
|
|
|
|
W1131, a potent STAT3 inhibitor, effectively triggers ferroptosis and suppresses cancer progression across various models including gastric cancer cell subcutaneous xenograft, organoids, and patient-derived xenograft (PD... |
|
T73805 |
Acetyl coenzyme A
|
|
|
|
Acetyl-coenzyme A (Acetyl-CoA), a membrane-impermeant central metabolic intermediate, plays a crucial role in the TCA cycle and oxidative phosphorylation metabolism. It also serves as the sole donor of acetyl groups for ... |
|
T83865 |
HP661
|
|
|
|
HP661, a selective inhibitor of mitochondrial complex I (NADH dehydrogenase), impedes complex I activity by 77.6% at 1 µM, demonstrating lesser inhibition towards complex III (28.1%) and no inhibitory effects on complexe... |
|
T80847 |
W1131 TFA
|
|
STAT
|
|
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. Besides mitigating chemoresistance to 5-FU in canc... |
|
T75656 |
Calcimycin hemimagnesium
|
|
|
|
Calcimycin (A-23187) hemimagnesium, an antibiotic and divalent cation ionophore (such as calcium and magnesium), serves various biological roles. It triggers Ca2+-dependent cell death by elevating intracellular calcium l... |
|
T79285 |
TRAP1-IN-1
|
|
HSP
|
|
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for TRAP1 compared to Grp94, destabilizes TRAP1 tetramers, and p... |
|
T35961 |
Prostaglandin Bx
|
|
|
|
PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytopr... |
